BRCA Gene Changes: Cancer Risk and Genetic Testing
The prevalence of harmful BRCA gene changes in the general population is about 0.2%–0.3% (or about 1 in 400). However, in certain populations that are geographically or culturally distinct, …
BRCA1 and BRCA2 (PDQ®) - NCI - National Cancer Institute
Key points: BRCA1/2 -associated ovarian cancers are more likely to have high-grade serous adenocarcinoma histologies. Occult lesions found in the fallopian tubes of BRCA carriers …
MRI, Surgery Reduce Cancer Deaths in Women with BRCA Changes
Apr 15, 2024 · For women with inherited harmful changes in BRCA genes, MRI surveillance and salpingo-oophorectomy can modestly reduce their risk of dying from breast and ovarian …
Cambios en el gen BRCA: el riesgo de cáncer y las pruebas genéticas
Los cambios dañinos en BRCA que se detectan en el tumor pueden ser hereditarios o haber surgido en otro momento de la vida de la persona. Por este motivo, si se identifica un cambio …
Study Pinpoints Potential Ovarian Cancer Driver - NCI
Apr 24, 2025 · A type of stem cell appears to fuel the formation of cancerous lesions in the fallopian tubes and the lesions’ transition to ovarian cancer, a new study shows.
Testing Olaparib for One or Two Years, with or without …
This phase III trial compares the effect of olaparib for one year versus two years, with or without bevacizumab, for the treatment of BRCA 1/2 mutated or homologous recombination deficient …
Researchers categorize thousands of BRCA2 mutations as …
Feb 14, 2025 · A team of researchers led by Shyam K. Sharan, Ph.D., Senior Investigator in the Mouse Cancer Genetics Program, has categorized over 6,500 possible single nucleotide …
Discovery – BRCA Connection to Breast and Ovarian Cancer
As a result of NCI's investment, people with a family history of breast and ovarian cancer can use their BRCA test results to help make informed decisions about screening and potential risk …
Causes and Risk Factors | Breast Cancer - NCI
Dec 2, 2025 · BRCA1 and BRCA2 (learn more at BRCA Gene Changes: Cancer Risk and Genetic Testing) PALB2 CHEK2 TP53 (Li-Fraumeni syndrome) CDH1 PTEN (Cowden syndrome and …
New on NCI’s Websites for November 2024 - NCI
Nov 1, 2024 · BRCA Gene Changes: Cancer Risk and Genetic Testing Certain inherited changes in the BRCA1 or BRCA2 genes can greatly increase a person’s risk for several types of cancer.