Visual Abstract. Active bowel inflammation disrupts the bowel cell lining, which causes the inflammatory T cells to secrete Granzyme B into the extracellular space, progressively accentuating the ...

Granzyme proteases are a family of serine enzymes principally secreted by cytotoxic T cells and natural killer cells to induce cell death in virally infected or malignant targets. Traditionally ...

Harvard Medical School scientists have identified a key protein in the human immune system that drives inflammatory and autoimmune conditions when it turns against the body. The protein, Granzyme K, ...

Visual Abstract. Active bowel inflammation disrupts the bowel cell lining, which causes the inflammatory T cells to secrete Granzyme B into the extracellular space, progressively accentuating the ...

Please provide your email address to receive an email when new articles are posted on . A protein known as granzyme K was recently shown to be a driver of inflammation by activating the complement ...

Researchers also found that the amount of granzyme protein present in joint tissue correlated with the severity of the disease, often measured as joint inflammation. This correlation was independent ...

Study uncovers a pathogenic subset of memory T-cells that promote tissue inflammation and highlights a potential target for treating nasal polyps and other inflammatory airway diseases. Study: ...

A Cytosite Biopharma Inc. patent describes prodrugs of granzyme B-targeting compounds reported to be useful as granzyme B-imaging agents for the diagnosis of cancer.