Case-cohort study design has been widely used for its cost-effectiveness. In any real study, there are always other important outcomes of interest beside the failure time that the original case-cohort ...

Main outcome measures Cumulative time dependent intake of preservatives, including those in industrial food brands, assessed ...

Different approaches to cohort study design in the context of biomarkers of aging. Biomarkers of aging are commonly validated using cross-sectional or longitudinal study designs. Cross-sectional ...

Background Insomnia symptoms are prevalent in older adults and linked to cardiovascular disease (CVD), but the role of long-term symptom trajectories remains unclear. We investigated associations ...