A new study, published today in Nature Communications, offers clues into how APOE isoforms differentially affect human microglia function in Alzheimer's disease. The study, led by Dr Sarah Marzi and ...

Aliria Rosa Piedrahita de Villegas surprised scientists when she remained sharp 30 years past her expected age of Alzheimer’s disease onset, as dictated by an autosomal-dominant E280A Paisa presenilin ...

Apolipoprotein E (apoE) isoforms E2, E3, and E4, are important determinants of plasma lipid concentrations, with the ε 4 allele particularly associated with heightened risk of coronary heart disease ...

The structure of ApoE has proven tricky to discern in its native state, namely, attached to lipoproteins. Now, scientists led by David Holtzman at Washington University in St. Louis have captured ...

Misplaced car keys, forgotten names and other lapses in memory are a normal part of life, especially as you age. However, more serious memory problems can be a sign of cognitive impairment or dementia ...