Boston, MA - TZDs (aka, glitazones) have become a popular choice of treatment for type II diabetes since their release on the US market four years ago. However, the agents suffered a serious setback ...
ATP-binding cassette transporters (ABCA1, ABCG1) and scavenger receptor class B type I (SR-BI) are the three most important cellular cholesterol transporters/receptor in regulating cholesterol efflux.
Knock-out mice and humans lacking the gene had no problems moving phosphatidylserine outside the cell. A team of researchers at Penn State University and Amherst College say they have data that casts ...
Researchers have demonstrated -- using fat cells derived from human stem cells -- that individual genetic variation can be used to predict whether the TZD rosiglitazone will produce the unwanted side ...
Background. Human immunodeficiency virus (HIV) infection is associated with increased cardiovascular risk and reduced high-density lipoprotein cholesterol (HDL-c). In vitro, HIV impairs ...
There are no curative treatments for Tangier disease, but gene therapy for ABCA1 has been highlighted as a potential avenue for treating the disease, say the researchers of the paper. Although gene ...
Despite certain structural similarities, some physicochemical profiles (notably lipophilicity) vary markedly between statins (Figure 1). The ability of statins to inhibit HMG-CoA reductase is largely ...
When digging for the maximum number of needles, it helps to start with a massive haystack. That strategy worked to pin rare variants in two novel genes to AD risk. Published November 21 in Nature ...
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