The San Francisco 49ers have beaten the Indianapolis Colts 48-27 on “Monday Night Football” behind Brock Purdy ’s career-high five touchdown passes. Christian McCaffrey racked up 146 total scrimmage yards and caught two touchdowns, while George Kittle totaled seven receptions for 115 yards and a TD before leaving the game with an ankle injury.

Monday Night Football closes out Week 16 with a huge matchup between the San Francisco 49ers and the Indianapolis Colts.

Philip Rivers starts again when he takes on the ferocious 49ers on "Monday Night Football." Here's score, highlights, stats and more for Colts-49ers.

The Week 16 edition of "Monday Night Football" between the Indianapolis Colts (8-7) and the San Francisco 49ers (11-4) will be remembered as the Brock Purdy game. The 49ers quarterback powered San Francisco to a 48-27 road victory with a career-high five passing touchdowns.

The San Francisco 49ers are headed to Indianapolis for a Week 16 matchup against the Colts, and they now officially know who they'll be facing under center. While it was expected that quarterback Philip Rivers would make his second consecutive start after coming out of...

The San Francisco 49ers offense is cruising and they were dominant in a win over the Indianapolis Colts. Here are the highlights.

Carolina is coming off a huge Week 11 win over Atlanta in which quarterback Bryce Young had a career day, passing for 448 yards and three touchdowns in the Panthers' 30-27 overtime victory. Rookie wideout Tetairoa McMillan also set career highs with eight catches for 130 yards and two touchdowns.

Listed as inactive for the 49ers were wide receiver Jordan Watkins, running back Jordan James, linebacker Nick Martin, linebacker Tatum Bethune, defensive lineman Sebastian Valdez, defensive lineman Sam Okuayinonu and defensive lineman Jordan Elliott. Elliott was a late addition ot the injury report with a knee issue.

Playoff football is in full effect for the San Francisco 49ers who will be hosting their first ever playoff game at Levi's Stadium. The 49ers spent the wild card weekend on a bye after clinching the No. 1 seed for homefield advantage throughout the playoffs.

The 49ers have arguably the toughest two-game closing stretch among the teams in playoff positions. They face the Chicago Bears in Week 17 and then take on the Seattle Seahawks in Week 18. The Seattle-San Francisco regular-season finale could be the No.